MyBioSource.com's TrpC7 Antibody is a Mouse monoclonal antibody. The TrpC7 Antibody was generated using TRPC7 as the antigen. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Immunofluorescence, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Background Info: Detects ~100kDa.
Scientific Background: Transient receptor potential cation channel, subfamily C, member 7, also known as TRPC7, is a non-selective cation channel that is directly activated by DAG. TrpC7 shows constitutive activity and susceptibility to negative regulation by extracellular Ca2+. Because of this, TrpC7 plays an important role in the Ca2+ signaling pathway (3). TrpC7 is also expressed abundantly in the heart, and combined with its ability to act as a Ca2+ channel, TrpC7 might contribute to the process of heart failure (4)